TY  - BOOK
AU  - Shargel,Leon
AU  - Wu-Pong,Susanna
AU  - Yu,Andrew B.C.
TI  - Applied biopharmaceutics & pharmacokinetics / : Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu
SN  - 9780071603935 (hardcover : alk. paper)
AV  - RM301.4 .S52 2012
U1  - 615.7 23
PY  - 2012///
CY  - New York, London
PB  - McGraw-Hill
KW  - Biopharmaceutics
KW  - Pharmacokinetics
KW  - Models, Chemical
N1  - Includes bibliographical references and index
; Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease
ER  -