TY - BOOK AU - Rosenbaum,Sara TI - Basic pharmacokinetics and pharmacodynamics: an integrated textbook and computer simulations SN - 9780470569061 (cloth) AV - RM301.5 .R655 2011 U1 - 615.7 22 PY - 2011/// CY - Hoboken, N.J. PB - John Wiley & Sons KW - Pharmacokinetics KW - Textbooks KW - Computer simulation KW - Drugs KW - Physiological effect KW - Computer Simulation KW - Pharmacological Phenomena N1 - Includes bibliographical references and index; Introduction to pharmacokinetics and pharmacodynamics -- Passage of drug through membranes -- Drug absorption -- Drug elimination -- Compartmental models -- Pharmacokinetics of an intravenous bolus injection in a one compartment model -- An intravenous bolus injection in the two compartment model -- Pharmacokinetics of extravascular drug administration -- Introduction to non-compartmental analysis -- Pharmacokinetics of the intravenous infusion in a one compartment model -- Multiple intravenous bolus injections in the one compartment model -- Multiple intermittent infusions -- Multiple oral doses -- Nonlinear pharmacokinetics -- Introduction to pharmacodynamic models and integrated pharmacokinetic- pharmacodynamics (PK-PD) models -- Mechanism based integrated pharmacokinetic-pharmacodynamic models ER -