000			02221nam a22003617a 4500
003			BUC
005			20220402062503.0
008			200120s2012 a|||g bi|| 00| 0 eng d
010			_a2011020446
020			_a9780071603935 (hardcover : alk. paper)
020			_a007160393X (hardcover : alk. paper)
020			_a9781259011115
040			_aBADR UNIVERSITY IN CAIRO _beng _cBADR UNIVERSITY IN CAIRO _erda
041	0		_aeng
050	0	0	_aRM301.4 _b.S52 2012
082	0	4	_223 _a615.7 _bSLA
100	1		_aShargel, Leon, _d1941-
245	1	0	_aApplied biopharmaceutics & pharmacokinetics / _bLeon Shargel, Susanna Wu-Pong, Andrew B.C. Yu.
246	1		_aApplied biopharmaceutics and pharmacokinetics.
250			_a.6th ed, _bInternational ed.
260			_aNew York : _aLondon : _bMcGraw-Hill, _c2012.
300			_axx, 811 p. : _bill. ; _c24 cm.
336			_236
504			_aIncludes bibliographical references and index.
505			_aIntroduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease.
650		0	_aBiopharmaceutics.
650		0	_aPharmacokinetics.
650		0	_aModels, Chemical.
700	1		_aWu-Pong, Susanna.
700	1		_aYu, Andrew B. C., _d1945-
902			_aH.Ali
942			_2ddc _cBK
999			_c2175 _d2175