000			01635cam a22003018a 4500
999			_c7630 _d7630
003			BUC
005			20200917111050.0
008			200917s2012 nju g b 001 0 eng
020			_a9781118028681 (cloth)
040			_aDNLM/DLC _cDLC _dDLC _bara _erda
041	0		_aeng
050	0	0	_aRM301.4 _b.S84 2012
082	0	0	_a615.7 _223 _bSKB
100	1		_aSugano, Kiyohiko.
245	1	0	_aBiopharmaceutics modeling and simulations : _btheory, practice, methods, and applications / _cKiyohiko Sugano.
260			_aHoboken, N.J. : _bJohn Wiley & Sons, _cc2012.
300			_axxxv, 483 p. : _bill. ; _c24 cm.
336			_236
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction -- Theoretical framework I : solubility -- Theoretical framework II : dissolution -- Theoretical framework III : biological membrane permeation -- Theoretical framework IV : gastrointestinal transit models and integration -- Physiology of gastrointestinal tract and other administration sites in humans and animals -- Drug parameters -- Validation of mechanistic models -- Bioequivalence and biopharmaceutical classification system -- Dose and particle size dependency -- Enabling formulations -- Food effect -- Biopharmaceutical modeling for miscellaneous cases -- Intestinal transporters -- Strategy in drug discovery and development -- Epistemology of biopharmaceutical modeling and good simulation practice.
650	1	2	_aBiopharmaceutics _xmethods.
650	2	2	_aComputer Simulation.
650	2	2	_aDrug Compounding _xmethods.
650	2	2	_aModels, Theoretical.
902			_ahali
942			_2ddc _cBK