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Classification of Epithelia                                                                Chapter 4  The Tissue Level of Organization   145

Epithelial cells have three basic shapes: squamous, cuboidal, and         Simple epithelia are also characteristic of regions in which
columnar. For classification purposes, we look at the superficial    secretion or absorption occurs. Examples are the lining of the
cells in a section perpendicular to both the apical surface and      intestines and the gas-exchange surfaces of the lungs. In these
the basement membrane. In sectional view, squamous cells
appear thin and flat, cuboidal cells look like little boxes, and     	4places, thinness is an advantage. It reduces the time required
columnar cells are tall and relatively slender rectangles.
                                                                     for materials to cross the epithelial barrier.
     Once you have determined whether the superficial cells               In a stratified epithelium, several layers of cells cover
are squamous, cuboidal, or columnar, then look at the number
of cell layers. There are only two options: simple or stratified.    the basement membrane. Stratified epithelia are generally
                                                                     located in areas that are exposed to mechanical or chemical
     If only one layer of cells covers the basement membrane,        stresses. The surface of the skin and the lining of the mouth are
that layer is a simple epithelium. Simple epithelia are neces-       examples.
sarily thin. All the cells have the same polarity, so the distance
from the nucleus to the basement membrane does not change            &T i p s T r i c k s
from one cell to the next.                                             To help you remember the meanings of the terms squamous
                                                                       and stratified, associate the word “squamous” with “scaly,” and
     Because they are so thin, simple epithelia are fragile. A sin-    the word “stratified” with “stratosphere,” an upper layer of
gle layer of cells cannot provide much mechanical protection,          Earth’s atmosphere.
so simple epithelia are located only in protected areas inside
the body. They line internal compartments and passageways,           Squamous Epithelia
such as the pleural, pericardial, and peritoneal cavities, the
heart chambers, and blood vessels.                                   The cells in a squamous epithelium (SKWA■ -mus; squama,
                                                                     plate or scale) are thin, flat, and somewhat irregular in shape,
                                                                     like pieces of a jigsaw puzzle (Figure 4–3). From the surface, the

Figure 4–3  Squamous Epithelia.                                                  Cytoplasm
                                                                                   Nucleus
   Simple Squamous Epithelium
     LOCATIONS: Mesothelia                                    Connective tissue                     LM × 238
     lining pleural, pericardial,    a Lining of peritoneal cavity                                  LM × 310
     and peritoneal cavities;
     endothelia lining heart                                                        Squamous
     and blood vessels; portions                                                 superficial cells
     of kidney tubules (thin
     sections of nephron loops);                                                    Stem cells
     inner lining of cornea;                                                        Basement
     alveoli of lungs                                                               membrane
     FUNCTIONS: Reduces                                                            Connective
     friction; controls vessel
     permeability; performs                                                            tissue
     absorption and secretion

   Stratified Squamous Epithelium
     LOCATIONS: Surface of
     skin; lining of mouth, throat,
     esophagus, rectum, anus,
     and vagina
     FUNCTIONS: Provides physical
     protection against abrasion,
     pathogens, and chemical attack

                                     b Surface of tongue
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