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Chapter 18  The Endocrine System   667

Figure 18–19  Endocrine Functions of the Kidneys.

                  Sunlight                                        Digestive
                                                                     tract

                  Cholesterol

                                                Epidermis                                                                                  HOMEOSTASIS

                  CholecSalucnifleigrohlt              choDleiceatalcriyferolDigtreascttive                                                     Normal
                                                                                                                                           blood pressure
Liver             Cholesterol                                                                HOMEOSTASIS
                                                                                                                                             and volume

                                                                                                  DISTURBED                                                HOMEOSTASIS
                                                                                                                                                           RESTORED
Intermediate                                           Epidermis                                  Falling blood                            HOMEOSTASIS     Rising blood
     form                        Parathyroid glands                                          pressure and volume                                 Normal    pressure and

                  Cholecalciferol                                 Dietary                                                                  blood pressure     volume
                                                                                                                                              and volume
                                                            cholecalciferol

Liver                                                                                        HOMEOKSiTdAnSeyIS                                                             HOMEOSTASIS

             Intermediate        Parathyroid glands         Stimulation of                   FallingDrIeSnTaUl RBED                                                        RESTORED
                   form                                      calcium and                      blpaornoeddsFsOfaulo2lrlweinagnbdlovoodlume                                       Increased
                                           PTH
           Calcitriol                                                                                                                                                      Risifnlugidbilnotoadke
                         Kidney                             phosphate ion                                                                    Increased                     preasnsdurreetaenndtion
                                                            absorption                                                                     red blood cell
 a The production of calcitriol                                                                              Kidney                                                           volume
                                                                                             FbarElelolrilyonetdgahsrfroeleodpnwoailetin    production                                                                                       	18
               Calcitriol                                                                                                                                                   Aldosterone
                                           PTH                    Stimulation of                and O2                                                                      secreteIndcreased
The Gonads Kidney                                                  calcium and                Renin released                                                                ADHasfnleudcidrreeittneetdnatkioen
                                                            phosphate ion                                                                                                   Stimulation of
                                                                  absorption                                                                       Increased                thirAstldosterone
                                                                                                                                           ACE  ArendgiboltoeondsicneIlIl
                                                                                                                                                                                secreted
                                                                                             AngiotensinogeEnrythropoAientigniotensin I           production
                                                                                                                released

InfoarmThaetiporonduacbtioonuotf tchalecitrrieopl roductive hormones of the testesb          TanhgeiroetleenassienRo-aeflnrdeinonsriteneleraoannsdeeedsryystthermopboeiegtiinnn, ianngdwainthotvheervaiectwivoatfitohAneDorHef nsienc-reted
and ovaries is presented in Table 18–7. In males, the inter-
stitial cells of the testes produce the male hormones known                                  angiotensinogen by renin                      ACE Angiotensin II              Stimulation of
                                                                                                                                                                           thirst
as androgens. Testosterone (tes-TOS-ter-o. n) is the most Angiotensinogen                                         Angiotensin I

important androgen. During embryonic development, the                                        b The release of renin and erythropoietin, and an overview of the renin-
production of testosterone affects the development of CNS                                       angiotensin-aldosterone system beginning with the activation of
structures, including hypothalamic nuclei, which will later                                     angiotensinogen by renin

Table 18–7   Hormones of the Reproductive System

Structure/Cells Hormone                    Primary Target         Hormonal Effect                                                          Regulatory Control

Testes                                                                                                                                     Stimulated by LH from the anterior lobe
                                                                                                                                           of the pituitary gland
Interstitial      Androgens                Most cells             Support functional maturation of sperm, protein
cells                                                             synthesis in skeletal muscles, male secondary sex                        Stimulated by FSH from the anterior lobe
                                                                  characteristics, and associated behaviors
                                                                                                                                           Stimulated by FSH and LH from the
Nurse cells       Inhibin                  Pituitary gland        Inhibits secretion of FSH                                                anterior lobe of the pituitary gland
                                                                                                                                           Stimulated by FSH from anterior lobe
Ovaries                                                                                                                                    Stimulated by LH from the anterior lobe
                                                                                                                                           of the pituitary gland
Follicular cells  Estrogens                Most cells             Support follicle maturation, female secondary sex
                                                                  characteristics, and associated behaviors
                  Inhibin                  Pituitary gland        Inhibits secretion of FSH
Corpus luteum     Progesterone             Uterus, mammary
                                           glands                 Prepares uterus for implantation; prepares mammary
                                                                  glands for secretory activity
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