Applied biopharmaceutics & pharmacokinetics / Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu.

Shargel, Leon, 1941-

Applied biopharmaceutics & pharmacokinetics / Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu. Applied biopharmaceutics and pharmacokinetics. - 6th ed, International ed. - New York : London : McGraw-Hill, 2012. - xx, 811 p. : ill. ; 24 cm.

Includes bibliographical references and index.


Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease.

9780071603935 (hardcover : alk. paper) 007160393X (hardcover : alk. paper) 9781259011115

2011020446


Biopharmaceutics.
Pharmacokinetics.
Models, Chemical.

RM301.4 / .S52 2012

615.7 / SLA

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