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C H A P T E R 1 5 Feeding Patients: Oral Diets and Enteral and Parenteral Nutrition                                417

Cyclic PN: infusing PN         Because rapid changes in the infusion rate can cause severe hyperglycemia or hypo-
at a constant rate for 8  glycemia and the potential for coma, convulsions, or death, rate changes must be made
to 12 hours/day.          incrementally. Continuous drip by pump infusion is needed to maintain a slow, constant
                          flow rate. If the rate of delivery falls behind or speeds up, the drip rate is adjusted to the
                          correct hourly rate only; no attempts are made to “catch up” to the ordered volume. Other
                          nursing management considerations appear in Box 15.6.

                               Overall, studies support the use of cyclic PN instead of continuous PN for stable
                          patients who require long-term or home PN (Stout and Cober, 2011). Infusions given over
                          a 10- to 14-hour period offer the patient periodic freedom from the equipment (Stout and
                          Cober, 2011) and allow serum glucose and insulin levels to drop during the periods when
                          PN is not infused, which may reduce the risk of impaired liver function related to excessive
                          glycogen and fat deposition. When it is given during the night, cyclic PN frees the patient
                          to participate in normal activities during the day.

                               During the switch from continuous to cyclic PN, the infusion time may be gradually
                          decreased by several hours each day, as ordered, and assessment is ongoing for signs of
                          glucose intolerance. To give the pancreas time to adjust to the decreasing glucose load,
                          the infusion rate may be tapered near the end of each cycle to reduce the risk of rebound

                          Box 15.6  NURSING MANAGEMENT CONSIDERATIONS FOR
                                    PARENTERAL NUTRITION

                          ■ Once parenteral nutrition solutions are prepared, they must be used immediately
                            or refrigerated. It is recommended that solutions be removed from the refrigera-
                            tor 1 hour before infusion because they must reach approximately room tempera-
                            ture before they are hung. Once hung, the solution is infused or discarded within
                            24 hours.

                          ■ Inspect the solution for “cracking” (appearance of a layer of fat on top or oily
                            globules in the solution), which may occur in three-in-one mixtures if the calcium
                            or phosphorus content is relatively high or if salt-poor albumin has been added.
                            A “cracked” solution cannot be infused; notify the pharmacy and the physician,
                            who may need to adjust the original PN order to eliminate or reduce the offending
                            component.

                          ■ Monitor the flow rate to avoid complications and ensure adequate intake.

                          ■ Observe for side effects of PN: weight gain greater than 1 kg/day (indicative of fluid
                            overload), elevated temperature or sepsis, high blood glucose levels, shortness of
                            breath, tightness of chest, anemia, nausea and vomiting, jaundice, allergy to protein
                            content of the solutions, pneumothorax, or cardiac arrhythmias.

                          ■ Monitor laboratory data and clinical signs to prevent the development of nutrient
                            deficiencies or toxicities.

                          ■ Some patients may feel hungry while receiving PN and should be allowed to eat, if
                            possible. If oral intake is contraindicated, give mouth care.

                          ■ Begin weaning the client from PN to EN or oral intake as soon as possible. Gradual
                            weaning is necessary to prevent rebound hypoglycemia. PN can be discontinued
                            when enteral intake (an oral diet, tube feeding, or combination of the two) provides
                            at least 60% of estimated calorie requirements.

                          ■ Patients who have permanently nonfunctional gastrointestinal tracts require PN
                            indefinitely. For home PN to be successful, clients and their families must be
                            physically and emotionally prepared. Intensive counseling focuses on preparation
                            and administration of the solution, catheter and equipment care, and assessment
                            skills as well as the psychological impact of permanent PN.
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