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enlargement. Recurrent lesions are more common with Sexually Transmitted Diseases 679
HSV-1 than with HSV-2 infection, and in general are less
painful and less extensive than primary lesions. Clark PE: Bladder cancer. Curr Opin Oncol 19:241, 2007. [Reviews the
• On histologic examination the vesicles of HSV infection diagnosis and management of both more superficial and advanced bladder
contain necrotic cells and fused multinucleate giant cells cancer.]
with intranuclear inclusions (Cowdry type A) that stain
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children born to mothers with genital herpes. Affected
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• HPV causes many proliferative lesions of the genital
mucosa, including condyloma acuminatum, precancerous Gori S, Porrozzi S, Roila F, et al: Germ cell tumours of the testis. Crit
lesions, and invasive cancers. Rev Oncol Hematol 53:141, 2005. [An informative review of the predis-
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