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C H A P T E R 1 9 Nutrition for Patients with Diabetes Mellitus  499

                         (Anderson, Riley, and Everette, 2012). The statistics are staggering (Centers for Disease
                         Control and Prevention [CDC], 2011).

                         ■ In 2010, an estimated 25.8 million Americans, or 8.3% of the population, had diabetes.
                           Of those cases, 7 million were undiagnosed.

                         ■ More than 35% of American adults have prediabetes based on fasting glucose or hemo-
                           globin A1c levels.

                         ■ In 2010, an estimated 1.9 million Americans aged 20 years or older were newly diag-
                           nosed with diabetes.

                         ■ Diabetes is the seventh leading cause of death in the United States.
                         ■ The estimated direct and indirect cost associated with diabetes in 2010 was $174 billion.

                           This estimate does not include the economic cost of undiagnosed diabetes or the im-
                           measurable costs of pain and suffering related to diabetes (Fowler, 2010).

Type 1 Diabetes:         Type 1 Diabetes
diabetes characterized
by the absence of        Type 1 diabetes, formerly known as insulin-dependent diabetes mellitus or juvenile dia-
insulin secretion.       betes, is characterized by the absence of insulin. It occurs from an autoimmune response
                         that damages or destroys pancreatic beta cells, leaving them unable to produce insulin.
Polyuria: excessive      Interaction between genetic susceptibility and environmental factors, such as viral infec-
urine excretion.         tion, is thought to be responsible for type 1 diabetes (Fowler, 2010). There is no known
                         way to prevent type 1 diabetes. All people with type 1 diabetes require exogenous insulin
Polydipsia: excessive    for survival.
thirst.
                              Although it can occur at any age, type 1 diabetes is most often detected in children
Polyphagia: excessive    and adolescents. The classic symptoms of polyuria, polydipsia, and polyphagia appear
appetite.                abruptly. Sometimes, the first sign of the disease is ketoacidosis. Type 1 diabetes accounts
                         for 5% to 10% of all diagnosed diabetes cases.
Ketoacidosis: the
accumulation of ketone   Type 2 Diabetes
bodies leading to
acidosis related to      Type 2 diabetes, previously referred to as non–insulin-dependent diabetes or adult-onset
incomplete breakdown     diabetes, can occur at any age and accounts for 90% to 95% of diagnosed cases of diabetes.
of fatty acids from      Unlike type 1 diabetes, in which there is a relatively abrupt and absolute end to insulin
carbohydrate deficiency  production, type 2 diabetes is a slowly progressive disease characterized by a combination
or inadequate carbohy-   of insulin resistance and relative insulin deficiency (Fowler, 2010). When cells do not re-
drate utilization.       spond to insulin as they should, the pancreas compensates by secreting higher than normal
                         levels of insulin. This period of impaired glucose tolerance/impaired fasting glucose
Insulin Resistance:      is known as prediabetes: glucose levels are normal or slightly elevated to levels below the
decreased cellular       criteria for diabetes and insulin levels are increased. Over time, chronic hyperinsulinemia
response to insulin.     leads to a decrease in the number of insulin receptors on the cells and a further reduction
                         in tissue sensitivity to insulin. Insulin production progressively falls to a deficient level,
Impaired Glucose         and frank type 2 diabetes develops. Because hyperglycemia develops gradually in type 2
Tolerance: 2-hour        diabetes and is often not severe enough for patients to recognize any of the classic diabetes
values in the oral       symptoms, type 2 diabetes may go undiagnosed for years. Many patients will have already
glucose tolerance test   developed complications by the time of diagnosis (Ahmad and Crandall, 2010).
of 140 to 199 mg/dL.
                              Risk factors for type 2 diabetes appear is Box 19.1. Overweight and obesity are strongly
Impaired Fasting         correlated with the development of type 2 diabetes and may be responsible for the growing
Glucose: fasting         epidemic (Fowler, 2010). Other risks are increasing age, lack of physical activity, and race/
plasma glucose levels    ethnicity. Abdominal obesity, abnormal serum lipid levels (low high-density lipoprotein
of 100 to 125 mg/dL.     cholesterol and/or high triglycerides), and hypertension are additional risks that are shared

Prediabetes: fasting
plasma glucose of 100
to 126 mg/dL or an oral
glucose tolerance test
of 140 to 199 mg/dL.

Hyperinsulinemia:
elevated blood levels
of insulin.
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